Joseph Arezzo

Our laboratory uses a variety of neurophysiologic techniques to explore normal and altered function in animal models. Experimental procedures include evoked potentials, ensemble and single unit recording procedures, current source density and whole nerve and spinal conduction velocity. For the past several decades, we have focused on the timing and spatial distribution of neuroelectric events in the neocortex of behaving monkeys. Current studies are examining complex auditory processing of components of speech and music in primary auditory cortex. The accurate and sensitive procedures developed for these studies have also been applied to disease models including transgenic and mutant mice, diabetic neuropathy, seizure disorders, neurotoxic insult and iatrogenic deficits of central and peripheral nerve function. In addition, we have participated in the “translation” of basic neuroscience principally to human clinical studies. We are currently participating in the design and conduct of multicenter Phase 1-4 clinical trials of experimental therapies intended to reduce or prevent diabetic and chemotherapy-induced neuropathies, to improve the treatment of chronic inflammatory demyelinating polyneuropathy and to monitor the treatment related CNS effects of compounds targeting HIV infection and depression.

Selected Publications