David H. Hall

Professor
Correlative fine structure and serial section reconstruction at the electron-microscopic level; morphology of nervous system mutants of Caenorhabditis elegans.

Kennedy Center
Room 601
(718) 430-2195
hall@aecom.yu.edu

Lab Webpages: http://neuroscience.aecom.yu.edu/labs/halllab/wormem/index.htm

www.wormatlas.org   www.wormimage.org   www.gfpworm.org

 

The soil nematode Caenorhabdidis elegans is a model system used to study the genetic control of cellular development. Our laboratory specializes in ultrastructural studies of the nervous system. We use serial thin sections, electron microscopy, and immunocytochemistry as primary tools to follow the development of identified neurons, particularly their axon outgrowth and synaptic connectivity.

We host the Center for C. elegans Anatomy, supported by NIH RR, and train students in anatomical methods for this system. Members of the lab are authoring several websites. www.wormatlas.org displays nematode anatomy in great detail through multiple applications including Slideable Worm, a Handbook of all cells and tissues, a Glossary, and selected html texts of classic papers. www.wormimage.org displays a searchable database of EM images of the nematode. www.gfpworm.org offers a searchable catalogue of expression patterns for gfp transgenes.

Wired Worm is a project aiming to complete the wiring diagram for the male adult nematode, working with Scott Emmons (Mol. Genetics, AECOM).

 

Selected Publications

Wang, J., Farr, G.W., Hall, D.H., Furtak, K., Dreier, L. and Horwich, A.L. (2009) An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregate formation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. PLoS Genetics Jan;5(1):e1000350. Epub 2009 Jan 23.

Stone, C.E., Hall, D.H. and Sundaram, M.V. (2009) Lipocalin signaling controls unicellular tube development in Caenorhabditis elegans. Developmental Biology, in press.

Hall, D.H. and Altun, Z. (2008) C. elegans Atlas. Cold Spring Harbor Laboratory Press, 340 pp.

Jauregui, A.R., Nguyen, K.C.Q., Hall, D.H. and Barr, M.M. (2008) C. elegans nephrocystin-1 and nephrocystin-4 modulate cilia development and morphogenesis. J Cell Biol.180: 973-88.

Ciche, T.A., Kim, K-s., Kaufman-Daszczuk, B., Nguyen, K.C.Q. and Hall, D.H. (2008) Cell invasion and matricide during symbiont transmission in nematodes. Appl Env Microbiol. 74: 2275-87.

Marza, E., Long, T., Saiardi, A., Eimer, S., Hall, D.H. and Lesa, G. M. (2008) Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling. Mol Biol of the Cell 19: 833-42.

Liu, Q., Chen, B., Hall, D.H., and Wang, Z. (2007) A quantum of neurotransmitter causes minis in multiple postsynaptic cells at the C. elegans neuromuscular junction. Dev. Neurobiology 67: 123-128.

Gattegno,T., Mittal, A., Valansi, A.V., Nguyen, C.Q., Hall, D.H., Chernomordik, L.V. and Podbilewicz, B. (2007) Genetic control of fusion pore expansion in the epidermis of C. elegans. Mol Biol of the Cell, 18: 1153-1166.

Bénard, C.Y., Boyanov, A., Hall, D.H. and Hobert, O. (2006) DIG-1, a novel giant protein non-autonomously mediates maintenance of nervous system architecture. Development 133: 3329-40.

Rowland, A.M., Olsen, J.G., Richmond, J.E., Hall, D.H. and Bamber, B.A. (2006) Presynaptic terminals independently regulate synaptic clustering and autophagy of GABAA receptors in Caenorhabditis elegans. J. Neuroscience 26: 1711-20.

Chen, B., Hall, D.H. and Chklovskii, D.B. (2006) Wiring optimization can relate neuronal structure and function. PNAS 103: 4723-4728.

Kao, G., Huang, C-c., Hedgecock, E.M., Hall, D.H. and Wadsworth, W. (2006) Role of the beta laminin beta subunit in C. elegans basement membrane function and development. Dev. Biol. 290: 211-219.

Altun, Z., Lints, R. and Hall, D.H. (2006) Nematode neurons. Anatomy and anatomical methods in Caenorhabditis elegans. Int. Rev. Neurobiol. 69: 1-35.

Berry, K., Bulow, H.E., Hall, D.H. and Hobert, O. (2003) Intracellular tube formation requires a C. elegans CLIC ion channel homolog. Science 302: 2134-37.

Melendez, A., Talloczy, Z., Seaman, M., Eskelinen, E-L., Hall, D.H., and Levine, B. (2003) Autophagy genes are essential for dauer development and lifespan extension in C. elegans. Science 301: 1387-91.

Huang, C-c., Hall, D.H., Hedgecock, E.M., Kao, G., Karantza, V., Vogel, B., Hutter, H., Chisholm, A.D.,Yurchenco, P.D., and Wadsworth, W.G. (2003) Laminin (subunits and their role in C. elegans development. Development 130: 3343-3358.

Herndon, L.A., Schmeissner, P.J., Dudaroneck, J.M., Brown, P.A., Listner, K.M., Paupard, M.C., Hall, D.H., and Driscoll, M. (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419: 788-794.

Aurelio, O., Hall, D.H., and Hobert, O. (2002) Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Science 295: 686-690.