Solomon L. Moshé

Professor
Developmental and behavioral neurobiology; mechanisms involved in the generation, expression, and modification of seizures with age.

Department of Neurology
Kennedy Center
Room 316
(718) 430-2447
moshe@aecom.yu.edu

Lab Webpage: epilepsy.aecom.yu.edu

 

Epilepsy and the developing brain

Clinical and research data suggest that the immature brain is more susceptible to seizures than the mature brain. The focus of the laboratory is to study, in animals, the epileptic process, its modifiers and consequences as a function of age and gender, translating novel findings to clinical applications. Projects include: 1) Identification of specialized subcortical circuits that modify seizures and are involved in the expression of increased seizure susceptibility of the immature brain. Ongoing studies indicate age and sex related differences in GABA function in the substantia nigra, a site critical involved in seizure control. These changes should be taken into account when drugs are developed to treat age-specific and sex-specific disorders in humans. 2) Identifications of factors responsible for the decreased vulnerability of the immature brain to seizure induced brain injury. 3) Identification of surrogate markers that may predict whether seizures may beget seizures or predict the development of an epileptic encephalopathy. 4) Determination of the relation of disorders of carbohydrate homeostasis to epilepsy and its consequences. Students interested in normal brain function or brain function during disease (epilepsy) can choose thesis projects utilizing a variety of in vivo and in vitro techniques available in the lab. The lab has received consistent funding since 1979.

 

Selected Publications

Galanopulou, A.S., Kyrozis, A., Claudio, O.I., Stanton, P.I. and Moshé, S.L., Sex-specific KCC2 expression function in rat substantia, Exp Neurol (in press).

Ravizza, T., Velísková, J., and Moshé, S.L., Testosterone regulates androgen and estrogen receptor immunoreactivity in rat substantia nigra pars reticulata. Neurosci Lett, 338:57-61 (2003).

Lado, F., Velísek, L and Moshé, S.L., The effect of electrical stimulation of the subthalamic nucleus on seizures is frequency-dependent, Epilepsia 44:157-163 (2003).

Hedberg, T.G., Velísková, J., Sperber, E.F., Nunes, M.L. and Moshé, S.L., Age-related differences in NMDA/metabotropic glutamate receptor binding in rat substantia nigra, Int J Dev Neurosci 21:95-104 (2003).

Ravizza, T., Galanopoulou, A.S., Velísková, J., and Moshé, S.L., Sex differences in androgen and estrogen receptor expression in rat substantia nigra during development : An immunohistochemical study. Neuroscience, 115:685-696 (2002).

Velísek L., Velísková J., and Moshé S.L., Electrical stimulation of substantia nigra pars reticulata is anticonvulsant in adult and young male rats. Experimental Neurology, 173, 145-152 (2002).

Haas, K.Z., Sperber, E.F., Opanashuk, L.A., Stanton, P.K., Moshé, S.L., Resistance of the immature hippocampus to morphologic and physiologic alterations following status epilepticus or kindling. Hippocampus 11:615-625 (2001).

Velísková, J., and Moshé S.L., Sexual dimorphism and developmental regulation of substantia nigra function. Annals of Neurology, 50:596-601 (2001).