Daniel M. Rosenbaum

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The focus of the lab is to study the underlying mechanisms of ischemic cell death. By obtaining a better understanding of the events that occur at a molecular level, therapies aimed at reducing neuronal damage may be developed. Specifically, we are focusing on the role of apoptosis in neuronal ischemia. The laboratory utilizes both cerebral and retinal models.
Another area of focus is neural stem and progenitor cells. The adult mammalian brain contains neural stem and progenitor cells that can proliferate, self-renew, and generate all of the cellular elements of the brain including neurons. During the past few years techniques have been developed which make it possible to isolate and expand, from developing or even adult CNS tissue, cells with properties characteristic of early neural multipotent progenitor or stem cells. These techniques have opened interesting new possibilities for the use of cells for CNS transplantation, neural replacement, and brain repair. This project will bring the rapidly expanding area of progenitor cells to bear on the problems of stroke and cerebral ischemia.

 

Rosenbaum, D.M., Rosenbaum, P.S., Gupta, A., Michaelson, D.M., Hall, D.H., Kessler, J.A. Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. Vision Research, 37:3445-3451, 1997.

Savitz, S.I., Rosenbaum, D.M. Apoptosis in neurological disease. Neurosurgery, 42:555-574, 1998.

Rosenbaum, D.M., D'Amore, J.D., Llena, J., Rybak, S., Balkany, A., Kessler, J.A. Pretreatment with intraventricular ATA decreases infarct size by inhibiting apoptosis following transient global ischemia in gerbils. Annals of Neurology, 43:654-660, 1998.

Aronica, E.M., Gorter, J.A., Grooms, S., Kessler, J.A., Bennett, M.V.L., Zukin, R.S., Rosenbaum, D.M. Aurintricarboxylic acid prevents GLUR2 mRNA down-regulation and delayed neurodegeneration in hippocampal CA1 neurons of gerbil after global ischemia. PNAS 95:7115-7120, 1998.

Rosenbaum, D.M., Rosenbaum, P.S., Gupta, H., Singh, M., Aggarwal, A., Hall, D.H., Roth, S., and Kessler, J.A. The role of the p53 protein in the selective vulnerability of the inner retina to transient ischemia. Investigative Ophthalmology and Visual Science 39:2132-2139, 1998.

Roth, S., Li, B., Zhang, C., Rosenbaum, P.S., Singh, M. and Rosenbaum, D.M. Retinal ischemic preconditioning in the in vivo rat retina: Signal transduction mechanisms. Exp. Eye Res., 70:755-765, 2000.

Rosenbaum, D.M., Gupta, G., Singh, M., D'Amore, J.Z., Zhang, H., Weidenheim, K. and Kessler, J.A. Fas (CD95/APO-1) plays a role in the pathophysiology of focal cerebral ischemia. J. Neurosci. Res., In Press.

Savitz, S.I., Anthony, J.V., Gupta, G., Barone, F., Erhardt, J.A.. and Rosenbaum, D.M. Carvedilol: Neuroprotection in transient focal ischemic stroke. J. Cerebral Blood Flow Metabolism, In Press.

 

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